Some of the disease one can face due to one hand cold is a symptom of nerves are disorders. Many times it such happens that a person is constantly putting weight on one of his one hand for a longer period of time. Thus this many result into nerve disorder and turn your hand cold. If your hand is getting cold then it is also a symptom of deficiency Vitamin D in your body. Thus one should get himself checked for it and take proper steps to cure it. Other symptoms can be of poor blood circulation when you sleep on one side of your hand for a longer time.