Iodine is necessary if your body is having its deficiency. Though Iodine Plus-2 due to its formula doesn't have any side effects, but if Iodine plus 2 is taken regularly then there are many side effects. It may aggravate the existing medical disorder and result into different types of problem like muscle and joint pain, carpal tunnel syndrome, tendonitis problems, gain or loss in weight, neck discomfort, neck enlargement, changes in hair and skin, loss of hair, problems and disturbances in bowel, irregularities in menstrual, loss of fertility, cholesterol issues, anxiety, depression, racing heart, poor growth, constipation, excessive tiredness, jaundice, dry skin, insomnia and more problems.