Why? Did you burn your hand cooking something? Burn blisters are tricky and treating them immediately after the burn is advisable. Clean the burn with fresh cold water. If you’ve got surgical gloves at home, use them. If you’ve got some burn cream in the first aid kit, then apply the cream gently using cotton. Aloe Vera is an efficient medicine and you can use the plant sap directly on the skin. Whatever you do, DO NOT wrap the burn up in plaster. Let it breathe for a while and use moleskin to cover the wound. If the pain persists, run as fast as you can to the doctor.